EVALUATION OF THE ANALGESIC EFFECT OF AQUEOUS ROOT EXTRACT OF Combretum platypterum (Welw) Hutch and Dalziel ON RODENT

Uwaya, O.D.; IDU, M; OMORHIENRHIEN, DE

doi:10.5281/zenodo.13291619

Authors

Uwaya, O.D. Department of Science Laboratory Technology, Faculty Of Life Sciences, University Of Benin, Benin City, Nigeria https://orcid.org/0009-0000-8721-1457
IDU, M Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Benin, Benin City, Nigeria https://orcid.org/0009-0000-8721-1457
OMORHIENRHIEN, DE Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Benin City, Nigeria https://orcid.org/0009-0000-8721-1457

DOI:

https://doi.org/10.5281/zenodo.13291619

Keywords:

Analgesic, Combretum platypterum, writhing, Ethno-medical, Plant extract

Abstract

Pain management is essential in many clinical cases, and an interdisciplinary approach eases suffering and improves the quality of life for those living with pain. The aim of this study was to test the analgesic effects of an aqueous root extract of Combretum platypterum. Three animal models were used: the acetic acid-induced writhing test, the hot plate model, and the tail flick model. In the acetic acid-induced writhing test, both the test extract and the standard drug reduced the number of abdominal constrictions and increased the percentage inhibition of writhing in a dose-dependent manner compared to the control. In the Hot Plate and Tail Flick models, the test extract and the standard drugs increased the pain threshold compared to the control group (****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05). The results of pharmacological tests performed in this study suggest that the plant extract has significant analgesic activity and confirms its ethno-medical use to treat back pains.

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2024-08-10

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Uwaya, O.D., IDU, M, & OMORHIENRHIEN, DE. (2024). EVALUATION OF THE ANALGESIC EFFECT OF AQUEOUS ROOT EXTRACT OF Combretum platypterum (Welw) Hutch and Dalziel ON RODENT. GVU Journal of Science, Health and Technology GVU J-SHT, 9(1), 47–52. https://doi.org/10.5281/zenodo.13291619

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EVALUATION OF THE ANALGESIC EFFECT OF AQUEOUS ROOT EXTRACT OF Combretum platypterum (Welw) Hutch and Dalziel ON RODENT

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